3-Iodothyronamine
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| 3-Iodothyronamine | |
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| IUPAC name | 4-[4-(2-Amino-ethyl)-2-iodo-phenoxy]-phenol |
| Other names | T1AM |
| Identifiers | |
| CAS number | [712349-95-6] |
| SMILES | OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1 |
| Properties | |
| Molecular formula | C14H14INO2 |
| Molar mass | 355.17 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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3-iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor.[1][2] When injected into rodents, T1AM causes a rapid drop in body temperature and alterations in blood pressure and heart rate.[3]
T1AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output.[4]
[edit] See also
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[edit] References
- ^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). "3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone". Nat. Med. 10 (6): 638–42. doi:. PMID 15146179.
- ^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). "Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues". J. Med. Chem. 49 (3): 1101–12. doi:. PMID 16451074.
- ^ New compound may act to keep thyroid activity in check. Retrieved on 2008-05-30.
- ^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). "Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function". PMID 17284482.
