3-hydroxybutyryl-CoA dehydrogenase
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In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) is an enzyme that catalyzes the chemical reaction
- (S)-3-hydroxybutanoyl-CoA + NADP+
3-acetoacetyl-CoA + NADPH + H+
Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP+, whereas its 3 products are 3-acetoacetyl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.
[edit] References
- IUBMB entry for 1.1.1.157
- BRENDA references for 1.1.1.157 (Recommended.)
- PubMed references for 1.1.1.157
- PubMed Central references for 1.1.1.157
- Google Scholar references for 1.1.1.157
- Madan VK, Hillmer P, Gottschalk G (1973). "Purification and properties of NADP-dependent L(+)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri". Eur. J. Biochem. 32: 51–6. doi:. PMID 4405720.
[edit] External links
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- The CAS registry number for this enzyme class is 39319-78-3.
[edit] Gene Ontology (GO) codes
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