2-dehydropantolactone reductase (B-specific)

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In enzymology, a 2-dehydropantolactone reductase (B-specific) (EC 1.1.1.214) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP⁺ 2-dehydropantolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP⁺, whereas its 3 products are 2-dehydropantolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP+ oxidoreductase (B-specific). Other names in common use include 2-oxopantoyl lactone reductase, 2-ketopantoyl lactone reductase, ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (B-specific).

[edit] References

• IUBMB entry for 1.1.1.214
• BRENDA references for 1.1.1.214 (Recommended.)
• PubMed references for 1.1.1.214
• PubMed Central references for 1.1.1.214
• Google Scholar references for 1.1.1.214
• Wilken DR, King HL Jr, Dyar RE (1975). "Ketopantoic acid and ketopantoyl lactone reductases Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate". J. Biol. Chem. 250: 2311–4. PMID 234966. 

[edit] External links

The CAS registry number for this enzyme class is 37211-75-9.

• IUBMB entry for 1.1.1.214

• KEGG entry for 1.1.1.214

• BRENDA entry for 1.1.1.214

• NiceZyme view of 1.1.1.214

• EC2PDB: PDB structures for 1.1.1.214

• PRIAM entry for 1.1.1.214

• PUMA2 entry for 1.1.1.214

• IntEnz: Integrated Enzyme entry for 1.1.1.214

• MetaCyc entry for 1.1.1.214

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019141: 2-dehydropantolactone reductase (B-specific)

• AMIGO entry for GO code 0019141: 2-dehydropantolactone reductase (B-specific)