2-dehydropantolactone reductase (A-specific)

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In enzymology, a 2-dehydropantolactone reductase (A-specific) (EC 1.1.1.168) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP⁺ $\rightleftharpoons$ 2-dehydropantolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP⁺, whereas its 3 products are 2-dehydropantolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP+ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).

[edit] References

IUBMB entry for 1.1.1.168
BRENDA references for 1.1.1.168 (Recommended.)
PubMed references for 1.1.1.168
PubMed Central references for 1.1.1.168
Google Scholar references for 1.1.1.168
King HL, Jr and Wilken DR (1972). "Ketopantoyl lactone and ketopantoic acid reductases Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 247: 4689–4695.
Wilken DR, King HL Jr, Dyar RE (1975). "Ketopantoic acid and ketopantoyl lactone reductases Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate". J. Biol. Chem. 250: 2311–4. PMID 234966.