2-alkenal reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-alkenal reductase (EC 1.3.1.74) is an enzyme that catalyzes the chemical reaction

n-alkanal + NAD(P)+ $\rightleftharpoons$ alk-2-enal + NAD(P)H + H⁺

The 3 substrates of this enzyme are n-alkanal, NAD⁺, and NADP⁺, whereas its 4 products are alk-2-enal, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.

[edit] References

IUBMB entry for 1.3.1.74
BRENDA references for 1.3.1.74 (Recommended.)
PubMed references for 1.3.1.74
PubMed Central references for 1.3.1.74
Google Scholar references for 1.3.1.74
D, Babiychuk E, Kushnir S, Asada K (2002). "The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes". Plant. Cell. Physiol. 43: 1445–55. doi:10.1093/pcp/pcf187. PMID 12514241.
Dick RA, Kwak MK, Sutter TR, Kensler TW (2001). "Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase". J. Biol. Chem. 276: 40803–10. doi:10.1074/jbc.M105487200. PMID 11524419.