12beta-hydroxysteroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 12beta-hydroxysteroid dehydrogenase (EC 1.1.1.238) is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP⁺ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H⁺

Thus, the two substrates of this enzyme are 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate and NADP⁺, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12beta-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), and dehydrogenase.

[edit] References

• IUBMB entry for 1.1.1.238
• BRENDA references for 1.1.1.238 (Recommended.)
• PubMed references for 1.1.1.238
• PubMed Central references for 1.1.1.238
• Google Scholar references for 1.1.1.238
• Edenharder R, Pfutzner A (1988). "Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum". Biochim. Biophys. Acta. 962: 362–70. PMID 3167086. 

[edit] External links

The CAS registry number for this enzyme class is 118390-62-8.

• IUBMB entry for 1.1.1.238

• KEGG entry for 1.1.1.238

• BRENDA entry for 1.1.1.238

• NiceZyme view of 1.1.1.238

• EC2PDB: PDB structures for 1.1.1.238

• PRIAM entry for 1.1.1.238

• PUMA2 entry for 1.1.1.238

• IntEnz: Integrated Enzyme entry for 1.1.1.238

• MetaCyc entry for 1.1.1.238

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047521: 12-beta-hydroxysteroid dehydrogenase

• AMIGO entry for GO code 0047521: 12-beta-hydroxysteroid dehydrogenase