11beta-hydroxysteroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 11beta-hydroxysteroid dehydrogenase (EC 1.1.1.146) is an enzyme that catalyzes the chemical reaction

an 11beta-hydroxysteroid + NADP⁺ an 11-oxosteroid + NADPH + H⁺

Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP⁺, whereas its 3 products are 11-oxosteroid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 11beta-hydroxysteroid:NADP+ 11-oxidoreductase. Other names in common use include corticosteroid 11beta-dehydrogenase, beta-hydroxysteroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase, corticosteroid 11-reductase, and dehydrogenase, 11beta-hydroxy steroid. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1XSE, 1XU7, 1XU9, 1Y5M, 1Y5R, 2BEL, 2ILT, and 2IRW.

[edit] References

• IUBMB entry for 1.1.1.146
• BRENDA references for 1.1.1.146 (Recommended.)
• PubMed references for 1.1.1.146
• PubMed Central references for 1.1.1.146
• Google Scholar references for 1.1.1.146
• Agarwal AK, Monder C, Eckstein B, White PC (1989). "Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase". J. Biol. Chem. 264: 18939–43. PMID 2808402. 
• Bush IE, Hunter SA, Meigs RA (1968). "Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver". Biochem. J. 107: 239–58. PMID 4384445. 
• Lakshmi V, Monder C (1988). "Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex". Endocrinology. 123: 2390–8. PMID 3139396. 
• Phillips DM, Lakshmi V, Monder C (1989). "Corticosteroid 11 beta-dehydrogenase in rat testis". Endocrinology. 125: 209–16. PMID 2661206. 

[edit] External links

The CAS registry number for this enzyme class is 9041-46-7.

• IUBMB entry for 1.1.1.146

• KEGG entry for 1.1.1.146

• BRENDA entry for 1.1.1.146

• NiceZyme view of 1.1.1.146

• EC2PDB: PDB structures for 1.1.1.146

• PRIAM entry for 1.1.1.146

• PUMA2 entry for 1.1.1.146

• IntEnz: Integrated Enzyme entry for 1.1.1.146

• MetaCyc entry for 1.1.1.146

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0033237: 11-beta-hydroxysteroid dehydrogenase (NADP+)

• AMIGO entry for GO code 0033237: 11-beta-hydroxysteroid dehydrogenase (NADP+)