(methionine synthase) reductase

From Wikipedia, the free encyclopedia

In enzymology, a [methionine synthase] reductase (EC 1.16.1.8) is an enzyme that catalyzes the chemical reaction

2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP⁺ $\rightleftharpoons$ 2 [methionine synthase]-cob(I)alamin + NADPH + H⁺ + 2 S-adenosyl-L-methionine

The 3 substrates of this enzyme are [[[methionine synthase]-methylcob(I)alamin]], S-adenosylhomocysteine, and NADP⁺, whereas its 4 products are [[[methionine synthase]-cob(I)alamin]], NADPH, H⁺, and S-adenosyl-L-methionine.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is [methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase. Other names in common use include methionine synthase cob(II)alamin reductase (methylating), methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin, and reducing). It employs one cofactor, flavoprotein.

[edit] References

IUBMB entry for 1.16.1.8
BRENDA references for 1.16.1.8 (Recommended.)
PubMed references for 1.16.1.8
PubMed Central references for 1.16.1.8
Google Scholar references for 1.16.1.8
Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA (1998). "Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria". Proc. Natl. Acad. Sci. U. S. A. 95: 3059–64. PMID 9501215.
Olteanu H, Banerjee R (2001). "Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation". J. Biol. Chem. 276: 35558–63. PMID 11466310.
Olteanu H, Munson T, Banerjee R (2002). "Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase". Biochemistry. 41: 13378–85. PMID 12416982.