YWHAG

From Wikipedia, the free encyclopedia

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

PDB rendering based on 2b05.

Available structures: 2b05

Identifiers

Symbol(s)

YWHAG; 14-3-3GAMMA

External IDs

OMIM: 605356 MGI: 108109 HomoloGene: 22725

Gene ontology
Molecular Function:	• protein kinase C binding • insulin-like growth factor receptor binding • protein kinase C inhibitor activity • protein domain specific binding
Biological Process:	• negative regulation of protein kinase activity • protein targeting • regulation of signal transduction • regulation of neuron differentiation • regulation of synaptic plasticity

Orthologs

Human

Mouse

Refseq

NM_012479 (mRNA)
NP_036611 (protein)

NM_018871 (mRNA)
NP_061359 (protein)

Location

Chr 7: 75.79 - 75.83 Mb

Chr 5: 136.19 - 136.22 Mb

Pubmed search

[1]

[2]

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, also known as YWHAG, is a human gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.^[1]

[edit] References

^ Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide.

[edit] Further reading

Morrison D (1994). "14-3-3: modulators of signaling proteins?". Science 266 (5182): 56–7. PMID 7939645.
Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
Roth D, Morgan A, Martin H, et al. (1994). "Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding.". Biochem. J. 301 ( Pt 1): 305–10. PMID 8037685.
Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules.". J. Biol. Chem. 271 (33): 20029–34. PMID 8702721.
Autieri MV, Haines DS, Romanic AM, Ohlstein EH (1997). "Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokine-stimulated human vascular smooth muscle cells.". Cell Growth Differ. 7 (11): 1453–60. PMID 8930394.
Ku NO, Liao J, Omary MB (1998). "Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.". EMBO J. 17 (7): 1892–906. doi:10.1093/emboj/17.7.1892. PMID 9524113.
Autieri MV, Carbone CJ (1999). "14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.". DNA Cell Biol. 18 (7): 555–64. doi:10.1089/104454999315105. PMID 10433554.
Horie M, Suzuki M, Takahashi E, Tanigami A (1999). "Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23.". Genomics 60 (2): 241–3. doi:10.1006/geno.1999.5887. PMID 10486217.
Dorner C, Ullrich A, Häring HU, Lammers R (1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.". J. Biol. Chem. 274 (47): 33654–60. PMID 10559254.
Pierrat B, Ito M, Hinz W, et al. (2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family.". Eur. J. Biochem. 267 (9): 2680–7. PMID 10785390.
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.". Biochem. J. 349 (Pt 2): 547–57. PMID 10880354.
Rena G, Prescott AR, Guo S, et al. (2001). "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.". Biochem. J. 354 (Pt 3): 605–12. PMID 11237865.
Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Peyrl A, Weitzdoerfer R, Gulesserian T, et al. (2003). "Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).". Electrophoresis 23 (1): 152–7. doi:10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T. PMID 11824616.
Johnson BA, Stehn JR, Yaffe MB, Blackwell TK (2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.". J. Biol. Chem. 277 (20): 18029–36. doi:10.1074/jbc.M110465200. PMID 11886850.
Yu T, Robb VA, Singh V, et al. (2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.". Biochem. J. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMID 11996670.
Graeser R, Gannon J, Poon RY, et al. (2003). "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.". J. Cell. Sci. 115 (Pt 17): 3479–90. PMID 12154078.
Nellist M, Goedbloed MA, de Winter C, et al. (2002). "Identification and characterization of the interaction between tuberin and 14-3-3zeta.". J. Biol. Chem. 277 (42): 39417–24. doi:10.1074/jbc.M204802200. PMID 12176984.