YWHAB

From Wikipedia, the free encyclopedia

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

PDB rendering based on 2bq0.

Available structures: 2bq0, 2c23

Identifiers

Symbol(s)

YWHAB; HS1; GW128; KCIP-1

External IDs

OMIM: 601289 MGI: 1891917 HomoloGene: 20724

Gene ontology
Molecular Function:	• monooxygenase activity • protein domain specific binding
Cellular Component:	• cytoplasm • perinuclear region of cytoplasm
Biological Process:	• protein targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003404 (mRNA)
NP_003395 (protein)

NM_018753 (mRNA)
NP_061223 (protein)

Location

Chr 20: 42.95 - 42.97 Mb

Chr 2: 163.69 - 163.71 Mb

Pubmed search

[1]

[2]

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, also known as YWHAB, is a human gene.

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.^[1]

[edit] See also

14-3-3 proteins

[edit] References

^ Entrez Gene: YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide.

[edit] Further reading

Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. PMID 16368544.