XRCC2

From Wikipedia, the free encyclopedia

X-ray repair complementing defective repair in Chinese hamster cells 2

Identifiers

XRCC2; DKFZp781P0919

External IDs

OMIM: 600375 MGI: 1927345 HomoloGene: 3964

Gene ontology
Molecular Function:	• DNA binding • ATP binding • DNA-dependent ATPase activity
Cellular Component:	• nucleus
Biological Process:	• DNA repair • DNA recombination • meiosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005431 (mRNA)
NP_005422 (protein)

NM_020570 (mRNA)
NP_065595 (protein)

Location

Chr 7: 151.97 - 152 Mb

Chr 5: 25.2 - 25.22 Mb

Pubmed search

[1]

[2]

X-ray repair complementing defective repair in Chinese hamster cells 2, also known as XRCC2, is a human gene.^[1]

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.^[1]

[edit] References

^ ^a ^b Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2.

[edit] Further reading

Jones NJ, Zhao Y, Siciliano MJ, Thompson LH (1995). "Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis.". Genomics 26 (3): 619-22. PMID 7607692.
Thacker J, Tambini CE, Simpson PJ, et al. (1995). "Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents.". Hum. Mol. Genet. 4 (1): 113-20. PMID 7711722.
Tambini CE, George AM, Rommens JM, et al. (1997). "The XRCC2 DNA repair gene: identification of a positional candidate.". Genomics 41 (1): 84-92. doi:10.1006/geno.1997.4636. PMID 9126486.
Cartwright R, Tambini CE, Simpson PJ, Thacker J (1998). "The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.". Nucleic Acids Res. 26 (13): 3084-9. PMID 9628903.
Liu N, Lamerdin JE, Tebbs RS, et al. (1998). "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.". Mol. Cell 1 (6): 783-93. PMID 9660962.
Cui X, Brenneman M, Meyne J, et al. (1999). "The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.". Mutat. Res. 434 (2): 75-88. PMID 10422536.
Johnson RD, Liu N, Jasin M (1999). "Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.". Nature 401 (6751): 397-9. doi:10.1038/43932. PMID 10517641.
Schild D, Lio YC, Collins DW, et al. (2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs.". J. Biol. Chem. 275 (22): 16443-9. doi:10.1074/jbc.M001473200. PMID 10749867.
Braybrooke JP, Spink KG, Thacker J, Hickson ID (2000). "The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2.". J. Biol. Chem. 275 (37): 29100-6. doi:10.1074/jbc.M002075200. PMID 10871607.
O'Regan P, Wilson C, Townsend S, Thacker J (2001). "XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding.". J. Biol. Chem. 276 (25): 22148-53. doi:10.1074/jbc.M102396200. PMID 11301337.
Miller KA, Yoshikawa DM, McConnell IR, et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.". J. Biol. Chem. 277 (10): 8406-11. doi:10.1074/jbc.M108306200. PMID 11744692.
Masson JY, Tarsounas MC, Stasiak AZ, et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs.". Genes Dev. 15 (24): 3296-307. doi:10.1101/gad.947001. PMID 11751635.
Kurumizaka H, Ikawa S, Nakada M, et al. (2002). "Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.". J. Biol. Chem. 277 (16): 14315-20. doi:10.1074/jbc.M105719200. PMID 11834724.
Wiese C, Collins DW, Albala JS, et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.". Nucleic Acids Res. 30 (4): 1001-8. PMID 11842112.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.". Nucleic Acids Res. 30 (4): 1009-15. PMID 11842113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Braybrooke JP, Li JL, Wu L, et al. (2004). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).". J. Biol. Chem. 278 (48): 48357-66. doi:10.1074/jbc.M308838200. PMID 12975363.
Mohindra A, Bolderson E, Stone J, et al. (2004). "A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.". Hum. Mol. Genet. 13 (2): 203-12. doi:10.1093/hmg/ddh022. PMID 14645207.
Tarsounas M, Davies AA, West SC (2004). "RAD51 localization and activation following DNA damage.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 359 (1441): 87-93. doi:10.1098/rstb.2003.1368. PMID 15065660.
Hussain S, Wilson JB, Medhurst AL, et al. (2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.". Hum. Mol. Genet. 13 (12): 1241-8. doi:10.1093/hmg/ddh135. PMID 15115758.