WNT16

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 16

Identifiers

External IDs

OMIM: 606267 MGI: 2136018 HomoloGene: 62175

Gene ontology
Molecular Function:	• signal transducer activity • extracellular matrix structural constituent
Cellular Component:	• extracellular region
Biological Process:	• Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016087 (mRNA)
NP_057171 (protein)

NM_053116 (mRNA)
NP_444346 (protein)

Location

Chr 7: 120.75 - 120.77 Mb

Chr 6: 22.24 - 22.25 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 16, also known as WNT16, is a human gene.^[1]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT16 wingless-type MMTV integration site family, member 16.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. PMID 8167409.
McWhirter JR, Neuteboom ST, Wancewicz EV, et al. (1999). "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11464–9. PMID 10500199.
Fear MW, Kelsell DP, Spurr NK, Barnes MR (2001). "Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues.". Biochem. Biophys. Res. Commun. 278 (3): 814–20. doi:10.1006/bbrc.2000.3852. PMID 11095990.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Katoh Y, Katoh M (2005). "Comparative genomics on Wnt16 orthologs.". Oncol. Rep. 13 (4): 771–5. PMID 15756456.
Mazieres J, You L, He B, et al. (2005). "Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.". Oncogene 24 (34): 5396–400. doi:10.1038/sj.onc.1208568. PMID 16007226.
Casagrande G, te Kronnie G, Basso G (2006). "The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.". Haematologica 91 (6): 765–71. PMID 16769578.