WIPF1

From Wikipedia, the free encyclopedia

WAS/WASL interacting protein family, member 1

PDB rendering based on 2a41.

Available structures: 2a41

Identifiers

Symbol(s)

WIPF1; MGC111041; PRPL-2; WASPIP; WIP

External IDs

OMIM: 602357 MGI: 2178801 HomoloGene: 86891

Gene ontology
Molecular Function:	• actin binding • profilin binding
Cellular Component:	• actin cytoskeleton
Biological Process:	• protein complex assembly • actin polymerization and/or depolymerization • actin filament-based movement

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001077269 (mRNA)
NP_001070737 (protein)

NM_153138 (mRNA)
NP_694778 (protein)

Location

Chr 2: 175.13 - 175.26 Mb

Chr 2: 73.23 - 73.33 Mb

Pubmed search

[1]

[2]

WAS/WASL interacting protein family, member 1, also known as WIPF1, is a human gene.^[1]

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: WIPF1 WAS/WASL interacting protein family, member 1.

[edit] Further reading

Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP.". Trends Cell Biol. 9 (1): 15-9. PMID 10087612.
Ramesh N, Antón IM, Hartwig JH, Geha RS (1998). "WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14671-6. PMID 9405671.
Antón IM, Lu W, Mayer BJ, et al. (1998). "The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck.". J. Biol. Chem. 273 (33): 20992-5. PMID 9694849.
Stewart DM, Tian L, Nelson DL (1999). "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein.". J. Immunol. 162 (8): 5019-24. PMID 10202051.
Vaduva G, Martinez-Quiles N, Anton IM, et al. (1999). "The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast.". J. Biol. Chem. 274 (24): 17103-8. PMID 10358064.
Moreau V, Frischknecht F, Reckmann I, et al. (2000). "A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.". Nat. Cell Biol. 2 (7): 441-8. doi:10.1038/35017080. PMID 10878810.
Vetterkind S, Miki H, Takenawa T, et al. (2002). "The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation.". J. Biol. Chem. 277 (1): 87-95. doi:10.1074/jbc.M104555200. PMID 11687573.
Antón IM, de la Fuente MA, Sims TN, et al. (2002). "WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.". Immunity 16 (2): 193-204. PMID 11869681.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238-46. doi:10.1074/jbc.M202783200. PMID 12029088.
Benesch S, Lommel S, Steffen A, et al. (2002). "Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.". J. Biol. Chem. 277 (40): 37771-6. doi:10.1074/jbc.M204145200. PMID 12147689.
Zettl M, Way M (2003). "The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs.". Curr. Biol. 12 (18): 1617-22. PMID 12372256.
Volkman BF, Prehoda KE, Scott JA, et al. (2002). "Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.". Cell 111 (4): 565-76. PMID 12437929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sasahara Y, Rachid R, Byrne MJ, et al. (2003). "Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation.". Mol. Cell 10 (6): 1269-81. PMID 12504004.
Luthi JN, Gandhi MJ, Drachman JG (2003). "X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP).". Exp. Hematol. 31 (2): 150-8. PMID 12591280.
Kinley AW, Weed SA, Weaver AM, et al. (2003). "Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion.". Curr. Biol. 13 (5): 384-93. PMID 12620186.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kim MK, Kim ES, Kim DS, et al. (2004). "Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling.". Biochim. Biophys. Acta 1690 (2): 134-40. doi:10.1016/j.bbadis.2004.06.007. PMID 15469902.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.