Winged helix turn helix

From Wikipedia, the free encyclopedia

The winged helix turn helix (wHTH) (SCOP 46785) is a DNA-binding domain which binds to specific DNA sequences. It is formed by a 3-helical bundle and a 3- or 4-strand beta-sheet (wing). Topology of helices and strands in the wHTH families may vary. In the transcription factor ETS[1] (IPR000418) wHTH folds into a helix-turn-helix motif on a four-stranded anti-parallel beta-sheet scaffold arranged in the order α1-β1-β2-α2-α3-β3-β4[2] (PDB 1R36) where the third helix is the DNA recognition helix.

[edit] See also

[edit] References

  1. ^ Sharrocks AD, Brown AL, Ling Y, Yates PR (1997). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371-87. PMID 9570133. 
  2. ^ Donaldson LW, Petersen JM, Graves BJ, McIntosh LP (1996). "Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif". EMBO J. 15 (1): 125-34. PMID 8598195. 


 This protein-related article is a stub. You can help Wikipedia by expanding it.