Windows Vista 64
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Windows Vista 64 is the 64-bit version of the Windows Vista family of Microsoft operating systems. It is different from Windows Vista (Vista 32) in that the operating system operates in the 64-bit mode of processors that support that mode. Those processers include AMD processors such as Athlon, Opteron, and Intel processers as well.
Windows Vista 64 can run 32-bit programs, but must run them in a subsystem called the syswow64 system. Most 32-bit programs can run natively, but there are many that cannot run at all.
For instance, The Visual Basic 6 IDE will (supposedly) run natively on Vista 32, but will not run at all on Vista 64. (insert link to microsoft page here).
See Also: List of compatible and incompatible programs for Windows Vista 64

