WDR6

From Wikipedia, the free encyclopedia


WD repeat domain 6
Identifiers
Symbol(s) WDR6; FLJ10218; MGC126756; MGC142027
External IDs OMIM: 606031 MGI: 1930140 HomoloGene: 88849
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11180 83669
Ensembl ENSG00000178252 ENSMUSG00000066357
Uniprot Q9NNW5 n/a
Refseq NM_018031 (mRNA)
NP_060501 (protein)		 NM_031392 (mRNA)
NP_113569 (protein)
Location Chr 3: 49.02 - 49.03 Mb Chr 9: 108.43 - 108.44 Mb
Pubmed search [1] [2]

WD repeat domain 6, also known as WDR6, is a human gene.[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.[1]

[edit] References

  1. ^ a b Entrez Gene: WDR6 WD repeat domain 6.

[edit] Further reading

  • Li D, Roberts R (2002). "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.". Cell. Mol. Life Sci. 58 (14): 2085-97. PMID 11814058. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Li D, Burch P, Gonzalez O, et al. (2000). "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene.". Biochem. Biophys. Res. Commun. 274 (1): 117-23. doi:10.1006/bbrc.2000.3012. PMID 10903905. 
  • Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS.". J. Biol. Chem. 277 (22): 19439-47. doi:10.1074/jbc.M111838200. PMID 11912194. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Xie X, Wang Z, Chen Y (2007). "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.". Mol. Cell. Biochem. 301 (1-2): 115-22. doi:10.1007/s11010-006-9402-5. PMID 17216128. 
 This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.