WDR5

From Wikipedia, the free encyclopedia


WD repeat domain 5
PDB rendering based on 2cnx.
Available structures: 2cnx, 2co0, 2g99, 2g9a, 2gnq, 2h13, 2h14, 2h68, 2h6k, 2h6n, 2h6q, 2h9l, 2h9m, 2h9n, 2h9p, 2o9k
Identifiers
Symbol(s) WDR5; BIG-3; SWD3
External IDs OMIM: 609012 MGI: 2155884 HomoloGene: 59931
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11091 140858
Ensembl ENSG00000196363 ENSMUSG00000026917
Uniprot P61964 Q3UNQ3
Refseq NM_017588 (mRNA)
NP_060058 (protein)		 NM_080848 (mRNA)
NP_543124 (protein)
Location Chr 9: 135.99 - 136.01 Mb Chr 2: 27.22 - 27.36 Mb
Pubmed search [1] [2]

WD repeat domain 5, also known as WDR5, is a human gene.[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: WDR5 WD repeat domain 5.

[edit] Further reading

  • Gori F, Divieti P, Demay MB (2002). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation.". J. Biol. Chem. 276 (49): 46515-22. doi:10.1074/jbc.M105757200. PMID 11551928. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wysocka J, Myers MP, Laherty CD, et al. (2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.". Genes Dev. 17 (7): 896-911. doi:10.1101/gad.252103. PMID 12670868. 
  • Gori F, Demay MB (2004). "BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro.". Endocrinology 145 (3): 1050-4. doi:10.1210/en.2003-1314. PMID 14657013. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Yokoyama A, Wang Z, Wysocka J, et al. (2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.". Mol. Cell. Biol. 24 (13): 5639-49. doi:10.1128/MCB.24.13.5639-5649.2004. PMID 15199122. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413. 
  • Wysocka J, Swigut T, Milne TA, et al. (2005). "WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.". Cell 121 (6): 859-72. doi:10.1016/j.cell.2005.03.036. PMID 15960974. 
  • Dou Y, Milne TA, Tackett AJ, et al. (2005). "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.". Cell 121 (6): 873-85. doi:10.1016/j.cell.2005.04.031. PMID 15960975. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gori F, Friedman L, Demay MB (2006). "Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo.". Journal of musculoskeletal & neuronal interactions 5 (4): 338-9. PMID 16340128. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Ruthenburg AJ, Wang W, Graybosch DM, et al. (2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.". Nat. Struct. Mol. Biol. 13 (8): 704-12. doi:10.1038/nsmb1119. PMID 16829959. 
  • Couture JF, Collazo E, Trievel RC (2006). "Molecular recognition of histone H3 by the WD40 protein WDR5.". Nat. Struct. Mol. Biol. 13 (8): 698-703. doi:10.1038/nsmb1116. PMID 16829960. 
  • Dou Y, Milne TA, Ruthenburg AJ, et al. (2006). "Regulation of MLL1 H3K4 methyltransferase activity by its core components.". Nat. Struct. Mol. Biol. 13 (8): 713-9. doi:10.1038/nsmb1128. PMID 16878130. 
  • Schuetz A, Allali-Hassani A, Martín F, et al. (2006). "Structural basis for molecular recognition and presentation of histone H3 by WDR5.". EMBO J. 25 (18): 4245-52. doi:10.1038/sj.emboj.7601316. PMID 16946699. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
 This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.