WDR45

From Wikipedia, the free encyclopedia


WD repeat domain 45
Identifiers
Symbol(s) WDR45; JM5; WDRX1; WIPI-4; WIPI4
External IDs OMIM: 300526 MGI: 1859606 HomoloGene: 48498
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11152 54636
Ensembl ENSG00000196998 ENSMUSG00000039382
Uniprot Q9Y484 Q91VM3
Refseq NM_001029896 (mRNA)
NP_001025067 (protein)		 NM_172372 (mRNA)
NP_758960 (protein)
Location Chr X: 48.82 - 48.85 Mb Chr X: 6.88 - 6.89 Mb
Pubmed search [1] [2]

WD repeat domain 45, also known as WDR45, is a human gene.[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: WDR45 WD repeat domain 45.

[edit] Further reading

  • Proikas-Cezanne T, Waddell S, Gaugel A, et al. (2005). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.". Oncogene 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Jeffries TR, Dove SK, Michell RH, Parker PJ (2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.". Mol. Biol. Cell 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMID 15020712. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
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