Vitamin-K-epoxide reductase (warfarin-sensitive)

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In enzymology, a vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.1.4.1) is an enzyme that catalyzes the chemical reaction

2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol $\rightleftharpoons$ 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two substrates of this enzyme are 2-methyl-3-phytyl-1,4-naphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase. This enzyme participates in biosynthesis of steroids. At least one compound, Warfarin is known to inhibit this enzyme.

[edit] References

IUBMB entry for 1.1.4.1
BRENDA references for 1.1.4.1 (Recommended.)
PubMed references for 1.1.4.1
PubMed Central references for 1.1.4.1
Google Scholar references for 1.1.4.1
Lee JJ, Fasco MJ (1984). "Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide". Biochemistry. 23: 2246–52. doi:10.1021/bi00305a024. PMID 6733086.
Mukharji I, Silverman RB (1985). "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U. S. A. 82: 2713–7. doi:10.1073/pnas.82.9.2713. PMID 3857611.
Whitlon DS, Sadowski JA, Suttie JW (1978). "Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition". Biochemistry. 17: 1371–7. doi:10.1021/bi00601a003. PMID 646989.