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| Vimentin 3' UTR protein-binding region |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
66.1 nucleotides |
| Avg identity: |
80% |
|
The vimentin 3' UTR protein-binding region is an RNA element that contains a Y shaped structure which has been shown to have protein binding activity.[1] The same region has been implicated in the control of mRNA localisation to the perinuclear region of the cytoplasm, possibly at sites of intermediate filament assembly.[2] The identity of the proteins involved and the localisation mechanism are not known.
[edit] References
- ^ Zehner, ZE; Shepherd RK, Gabryszuk J, Fu TF, Al-Ali M, Holmes WM (1997). "RNA-protein interactions within the 3' untranslated region of vimentin mRNA". Nucleic Acids Res 25: 3362–3370. doi:10.1093/nar/25.16.3362. PMID 9241253.
- ^ Bermano, G; Shepherd RK, Zehner ZE, Hesketh JE (2001). "Perinuclear mRNA localisation by vimentin 3'-untranslated region requires a 100 nucleotide sequence and intermediate filaments". FEBS Lett 497: 77–81. doi:10.1016/S0014-5793(01)02438-3. PMID 11377416.
[edit] External links
