Vesamicol
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| Vesamicol | |
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| IUPAC name | 2-(4-Phenyl-1-piperidinyl)-1-cyclohexanol |
| Identifiers | |
| CAS number | [22232-64-0] |
| PubChem | |
| SMILES | C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O |
| Properties | |
| Molecular formula | C17H25NO |
| Molar mass | 259.39 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Vesamicol is an experimental drug, acting presynaptically on acetylcholine (ACh) synthesis.
[edit] Mechanism of action
Vesamicol can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the post-synaptic ACh receptor. Vesamicol causes a non-competitive and reversible block of the intracellular transporter responsible for carrying newly synthesised ACh into storage vesicles in the pre-synaptic nerve terminal. This transport process is driven by a proton gradient between cell organelles and the cytoplasm.
[edit] References
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