VAT1

From Wikipedia, the free encyclopedia

Vesicle amine transport protein 1 homolog (T. californica)

Identifiers

VAT1; FLJ20230; VATI

External IDs

OMIM: 604631 MGI: 1349450 HomoloGene: 36200

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • oxidoreductase activity
Cellular Component:	• nucleus • synaptic vesicle • integral to membrane
Biological Process:	• cell growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006373 (mRNA)
NP_006364 (protein)

NM_012037 (mRNA)
NP_036167 (protein)

Location

Chr 17: 38.42 - 38.43 Mb

Chr 11: 101.27 - 101.28 Mb

Pubmed search

[1]

[2]

Vesicle amine transport protein 1 homolog (T. californica), also known as VAT1, is a human gene.^[1]

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: VAT1 vesicle amine transport protein 1 homolog (T. californica).

[edit] Further reading

Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.". Science 266 (5182): 66–71. PMID 7545954.
Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene.". Hum. Mol. Genet. 4 (8): 1259–66. PMID 7581362.
Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.". Genomics 25 (1): 256–63. PMID 7774926.
Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "The search for BRCA1.". Cancer Res. 54 (24): 6374–82. PMID 7987831.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Smith TM, Lee MK, Szabo CI, et al. (1997). "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.". Genome Res. 6 (11): 1029–49. PMID 8938427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.