VARS

From Wikipedia, the free encyclopedia

Valyl-tRNA synthetase

Identifiers

VARS; G7A; VARS2

External IDs

OMIM: 192150 MGI: 90675 HomoloGene: 4587

Gene ontology
Molecular Function:	• nucleotide binding • valine-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• intracellular • mitochondrion
Biological Process:	• translational elongation • valyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001133527 (mRNA)
XP_001133527 (protein)

NM_011690 (mRNA)
NP_035820 (protein)

Location

Chr c6_COX: 31.88 - 31.9 Mb

Chr 17: 34.61 - 34.62 Mb

Pubmed search

[1]

[2]

Valyl-tRNA synthetase, also known as VARS, is a human gene.^[1]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: VARS valyl-tRNA synthetase.

[edit] Further reading

Hsieh SL, Campbell RD (1991). "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase.". Biochem. J. 278 ( Pt 3): 809–16. PMID 1898367.
Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.". EMBO J. 8 (8): 2305–12. PMID 2477242.
Bec G, Kerjan P, Zha XD, Waller JP (1990). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1.". J. Biol. Chem. 264 (35): 21131–7. PMID 2556394.
Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL (1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor.". FEBS Lett. 238 (2): 262–4. PMID 3169261.
Bec G, Kerjan P, Waller JP (1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation.". J. Biol. Chem. 269 (3): 2086–92. PMID 8294461.
Vilalta A, Donovan D, Wood L, et al. (1993). "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.". Gene 123 (2): 181–6. PMID 8428657.
Motorin Y (1996). "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences.". Gene 170 (2): 289–91. PMID 8666263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bonnefond L, Fender A, Rudinger-Thirion J, et al. (2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.". Biochemistry 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Jiang S, Wolfe CL, Warrington JA, Norcum MT (2005). "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit.". FEBS Lett. 579 (27): 6049–54. doi:10.1016/j.febslet.2005.09.062. PMID 16229838.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.