VAPB

From Wikipedia, the free encyclopedia

VAMP (vesicle-associated membrane protein)-associated protein B and C

Identifiers

VAPB; ALS8; VAMP-B; VAMP-C; VAP-B; VAP-C

External IDs

OMIM: 605704 MGI: 1928744 HomoloGene: 36163

Gene ontology
Molecular Function:	• structural molecule activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein complex assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004738 (mRNA)
NP_004729 (protein)

NM_019806 (mRNA)
NP_062780 (protein)

Location

Chr 20: 56.4 - 56.46 Mb

Chr 2: 173.38 - 173.43 Mb

Pubmed search

[1]

[2]

VAMP (vesicle-associated membrane protein)-associated protein B and C, also known as VAPB, is a human gene.^[1]

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.^[1]

[edit] References

^ ^a ^b Entrez Gene: VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C.

[edit] Further reading

Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
Bastepe M, Pincus JE, Jüppner H (2000). "Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13.". Mol. Cell. Probes 13 (6): 449–51. doi:10.1006/mcpr.1999.0271. PMID 10657150.
Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.". J. Immunol. 164 (11): 5850–7. PMID 10820264.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.". Blood 100 (3): 1081–3. PMID 12130530.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nishimura AL, Mitne-Neto M, Silva HC, et al. (2004). "A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13.". J. Med. Genet. 41 (4): 315–20. PMID 15060112.
Nishimura AL, Mitne-Neto M, Silva HC, et al. (2005). "A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.". Am. J. Hum. Genet. 75 (5): 822–31. doi:10.1086/425287. PMID 15372378.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction.". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamamoto I, Nishimura Y, Okamoto T, et al. (2005). "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.". J. Virol. 79 (21): 13473–82. doi:10.1128/JVI.79.21.13473-13482.2005. PMID 16227268.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Perry RJ, Ridgway ND (2006). "Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.". Mol. Biol. Cell 17 (6): 2604–16. doi:10.1091/mbc.E06-01-0060. PMID 16571669.
Conforti FL, Sprovieri T, Mazzei R, et al. (2006). "Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.". Journal of negative results in biomedicine 5: 7. doi:10.1186/1477-5751-5-7. PMID 16729899.
Kanekura K, Nishimoto I, Aiso S, Matsuoka M (2006). "Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).". J. Biol. Chem. 281 (40): 30223–33. doi:10.1074/jbc.M605049200. PMID 16891305.