USP6

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 6 (Tre-2 oncogene)

Identifiers

USP6; TRE2; HRP1; TRE17; Tre-2

External IDs

Gene ontology
Molecular Function:	• nucleic acid binding • cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • peptidase activity
Cellular Component:	• lysosome
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

XM_001134439 (mRNA)
XP_001134439 (protein)

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Location

Chr 17: 4.97 - 5.02 Mb

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Pubmed search

[1]

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Ubiquitin specific peptidase 6 (Tre-2 oncogene), also known as USP6, is a human gene.^[1]

[edit] References

^ Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene).

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
Hoogendijk JE, Hensels GW, Gabreëls-Festen AA, et al. (1992). "De-novo mutation in hereditary motor and sensory neuropathy type I.". Lancet 339 (8801): 1081–2. PMID 1349106.
Nakamura T, Hillova J, Mariage-Samson R, et al. (1992). "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.". Oncogene 7 (4): 733–41. PMID 1565468.
Papa FR, Hochstrasser M (1993). "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.". Nature 366 (6453): 313–9. doi:10.1038/366313a0. PMID 8247125.
Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.". Gene 131 (2): 209–15. PMID 8406013.
Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.". DNA Cell Biol. 12 (2): 107–18. PMID 8471161.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMID 12604796.
Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.". Mol. Cell. Biol. 23 (6): 2151–61. PMID 12612085.
Bizimungu C, De Neve N, Burny A, et al. (2003). "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.". Biochem. Biophys. Res. Commun. 310 (2): 498–504. PMID 14521938.
Oliveira AM, Hsi BL, Weremowicz S, et al. (2004). "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.". Cancer Res. 64 (6): 1920–3. PMID 15026324.
Oliveira AM, Perez-Atayde AR, Inwards CY, et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.". Am. J. Pathol. 165 (5): 1773–80. PMID 15509545.
Martinu L, Masuda-Robens JM, Robertson SE, et al. (2004). "The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004. PMID 15509780.
Oliveira AM, Perez-Atayde AR, Dal Cin P, et al. (2005). "Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes.". Oncogene 24 (21): 3419–26. doi:10.1038/sj.onc.1208506. PMID 15735689.
Bizimungu C, Vandenbol M (2005). "At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity.". Biochem. Biophys. Res. Commun. 335 (3): 883–90. doi:10.1016/j.bbrc.2005.07.159. PMID 16099424.
Shen C, Ye Y, Robertson SE, et al. (2006). "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.". J. Biol. Chem. 280 (43): 35967–73. doi:10.1074/jbc.M505220200. PMID 16127172.
Dechamps C, Bach S, Portetelle D, Vandenbol M (2006). "The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton.". Biotechnol. Lett. 28 (4): 223–31. doi:10.1007/s10529-005-5523-2. PMID 16555005.