USP2

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 2

PDB rendering based on 2hd5.

Available structures: 2hd5, 2ibi

Identifiers

Symbol(s)

USP2; UBP41; USP9

External IDs

OMIM: 604725 MGI: 1858178 HomoloGene: 3098

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • protein binding
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004205 (mRNA)
NP_004196 (protein)

NM_016808 (mRNA)
NP_058088 (protein)

Location

Chr 11: 118.73 - 118.76 Mb

Chr 9: 43.82 - 43.85 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 2, also known as USP2, is a human gene.^[1]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: USP2 ubiquitin specific peptidase 2.

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Baek SH, Choi KS, Yoo YJ, et al. (1997). "Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle.". J. Biol. Chem. 272 (41): 25560-5. PMID 9325273.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gewies A, Grimm S (2003). "UBP41 is a proapoptotic ubiquitin-specific protease.". Cancer Res. 63 (3): 682-8. PMID 12566314.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Graner E, Tang D, Rossi S, et al. (2004). "The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.". Cancer Cell 5 (3): 253-61. PMID 15050917.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Stevenson LF, Sparks A, Allende-Vega N, et al. (2007). "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.". EMBO J. 26 (4): 976-86. doi:10.1038/sj.emboj.7601567. PMID 17290220.