USF2

From Wikipedia, the free encyclopedia

Upstream transcription factor 2, c-fos interacting

Identifiers

External IDs

OMIM: 600390 MGI: 99961 HomoloGene: 2527

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • transcription activator activity • transcription regulator activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • lactation • regulation of transcription • positive regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003367 (mRNA)
NP_003358 (protein)

XM_001001413 (mRNA)
XP_001001413 (protein)

Location

Chr 19: 40.45 - 40.46 Mb

n/a

Pubmed search

[1]

[2]

Upstream transcription factor 2, c-fos interacting, also known as USF2, is a human gene.^[1]

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting.

[edit] Further reading

Corre S, Galibert MD (2006). "[USF as a key regulatory element of gene expression]". Med Sci (Paris) 22 (1): 62–7. PMID 16386222.
Sirito M, Walker S, Lin Q, et al. (1993). "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers.". Gene Expr. 2 (3): 231–40. PMID 1450663.
Blanar MA, Rutter WJ (1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos.". Science 256 (5059): 1014–8. PMID 1589769.
Viollet B, Lefrançois-Martinez AM, Henrion A, et al. (1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.". J. Biol. Chem. 271 (3): 1405–15. PMID 8576131.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Groenen PM, Garcia E, Debeer P, et al. (1997). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia.". Genomics 38 (2): 141–8. PMID 8954795.
Ghosh AK, Datta PK, Jacob ST (1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo.". Oncogene 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
Kurschner C, Morgan JI (1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity.". Biochem. Biophys. Res. Commun. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
Breen GA, Jordan EM (1997). "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2.". J. Biol. Chem. 272 (16): 10538–42. PMID 9099698.
Nechushtan H, Zhang Z, Razin E (1997). "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level.". Blood 89 (8): 2999–3008. PMID 9108421.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Breen GA, Jordan EM (1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300.". Biochim. Biophys. Acta 1428 (2-3): 169–76. PMID 10434034.
Kumari D, Usdin K (2001). "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome.". J. Biol. Chem. 276 (6): 4357–64. doi:10.1074/jbc.M009629200. PMID 11058604.
Kolonics A, Apáti A, Nahajevszky S, et al. (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia.". Haematologia (Budap) 31 (2): 125–38. PMID 11583024.
Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2.". Biochem. J. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMID 11945176.
Villavicencio EH, Yoon JW, Frank DJ, et al. (2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF.". Genesis 32 (4): 247–58. PMID 11948912.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Moore ML, Park EA, McMillin JB (2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.". J. Biol. Chem. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
Pickwell GV, Shih H, Quattrochi LC (2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation.". Biochem. Pharmacol. 65 (7): 1087–96. PMID 12663044.
Zhu J, Giannola DM, Zhang Y, et al. (2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.