UPK1B

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Uroplakin 1B
Identifiers
Symbol(s) UPK1B; TSPAN20; UPIB; UPK1
External IDs OMIM: 602380 MGI: 98912 HomoloGene: 5065
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7348 22268
Ensembl ENSG00000114638 ENSMUSG00000049436
Uniprot O75841 Q9Z2C6
Refseq NM_006952 (mRNA)
NP_008883 (protein)		 NM_178924 (mRNA)
NP_849255 (protein)
Location Chr 3: 120.38 - 120.41 Mb Chr 16: 38.69 - 38.72 Mb
Pubmed search [1] [2]

Uroplakin 1B, also known as UPK1B, is a human gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: UPK1B uroplakin 1B.

[edit] Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143-51. PMID 11739647. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Wu XR, Medina JJ, Sun TT (1996). "Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells.". J. Biol. Chem. 270 (50): 29752-9. PMID 8530366. 
  • Finch JL, Webb GC, Evdokiou A, Cowled PA (1997). "Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism.". Genomics 40 (3): 501-3. doi:10.1006/geno.1996.4589. PMID 9073521. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Yuasa T, Yoshiki T, Tanaka T, et al. (1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.". Jpn. J. Cancer Res. 89 (9): 879-82. PMID 9818021. 
  • Lobban ED, Smith BA, Hall GD, et al. (1998). "Uroplakin gene expression by normal and neoplastic human urothelium.". Am. J. Pathol. 153 (6): 1957-67. PMID 9846985. 
  • Finch JL, Miller J, Aspinall JO, Cowled PA (1999). "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue.". Int. J. Cancer 80 (4): 533-8. PMID 9935153. 
  • Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract.". Am. J. Pathol. 155 (4): 1047-50. PMID 10514386. 
  • Olsburgh J, Weeks R, Selby P, Southgate J (2002). "Human uroplakin lb gene structure and promoter analysis.". Biochim. Biophys. Acta 1576 (1-2): 163-70. PMID 12031497. 
  • Deng FM, Liang FX, Tu L, et al. (2003). "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly.". J. Cell Biol. 159 (4): 685-94. doi:10.1083/jcb.200204102. PMID 12446744. 
  • Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum.". Mol. Biol. Cell 13 (12): 4221-30. doi:10.1091/mbc.E02-04-0211. PMID 12475947. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Varga AE, Leonardos L, Jackson P, et al. (2004). "Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma.". Neoplasia 6 (2): 128-35. doi:10.1593/neo.03337. PMID 15140401. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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