UNC5C

From Wikipedia, the free encyclopedia

Unc-5 homolog C (C. elegans)

Identifiers

UNC5C; UNC5H3

External IDs

OMIM: 603610 MGI: 1095412 HomoloGene: 2765

Gene ontology
Molecular Function:	• receptor activity • netrin receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• apoptosis • signal transduction • multicellular organismal development • axon guidance • brain development • regulation of cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003728 (mRNA)
NP_003719 (protein)

NM_009472 (mRNA)
NP_033498 (protein)

Location

Chr 4: 96.31 - 96.69 Mb

Chr 3: 141.4 - 141.77 Mb

Pubmed search

[1]

[2]

Unc-5 homolog C (C. elegans), also known as UNC5C, is a human gene.^[1]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.^[1]

[edit] References

^ ^a ^b Entrez Gene: UNC5C unc-5 homolog C (C. elegans).

[edit] Further reading

Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions.". Biochem. Cell Biol. 78 (5): 569–75. PMID 11103947.
Livesey FJ (2001). "Netrins and netrin receptors.". Cell. Mol. Life Sci. 56 (1-2): 62–8. PMID 11213262.
Leonardo ED, Hinck L, Masu M, et al. (1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.". Nature 386 (6627): 833–8. doi:10.1038/386833a0. PMID 9126742.
Ackerman SL, Knowles BB (1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.". Genomics 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. doi:10.1073/pnas.0738063100. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin.". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation.". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMID 15574733.
Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMID 15729359.
Li W, Aurandt J, Jürgensen C, et al. (2006). "FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5.". J. Cell. Sci. 119 (Pt 1): 47–55. doi:10.1242/jcs.02697. PMID 16371650.
Bernet A, Mazelin L, Coissieux MM, et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies.". Gastroenterology 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMID 17967459.