ULBP3

From Wikipedia, the free encyclopedia

UL16 binding protein 3

PDB rendering based on 1kcg.

Available structures: 1kcg

Identifiers

Symbol(s)

ULBP3; RAET1N

External IDs

OMIM: 605699

Gene ontology
Molecular Function:	• MHC class I receptor activity • GPI anchor binding
Cellular Component:	• membrane • MHC class I protein complex
Biological Process:	• antigen processing and presentation • natural killer cell activation

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_024518 (mRNA)
NP_078794 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 6: 150.43 - 150.43 Mb

n/a

Pubmed search

[1]

n/a

UL16 binding protein 3, also known as ULBP3, is a human gene.^[1]

[edit] References

^ Entrez Gene: ULBP3 UL16 binding protein 3.

[edit] Further reading

Cerwenka A, Lanier LL (2004). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer.". Tissue Antigens 61 (5): 335-43. PMID 12753652.
Eleme K, Taner SB, Onfelt B, et al. (2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.". J. Exp. Med. 199 (7): 1005-10. doi:10.1084/jem.20032194. PMID 15051759.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Radosavljevic M, Cuillerier B, Wilson MJ, et al. (2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.". Genomics 79 (1): 114-23. doi:10.1006/geno.2001.6673. PMID 11827464.
Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671-9. PMID 11777960.
Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039-49. PMID 11754823.
Steinle A, Li P, Morris DL, et al. (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.". Immunogenetics 53 (4): 279-87. PMID 11491531.
Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123-33. PMID 11239445.