UHMK1

From Wikipedia, the free encyclopedia

U2AF homology motif (UHM) kinase 1

Identifiers

UHMK1; KIS; Kist

External IDs

OMIM: 608849 MGI: 1341908 HomoloGene: 7801

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• cell cycle arrest • peptidyl-serine phosphorylation • protein amino acid autophosphorylation • regulation of protein export from nucleus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_175866 (mRNA)
NP_787062 (protein)

NM_010633 (mRNA)
NP_034763 (protein)

Location

Chr 1: 160.73 - 160.77 Mb

Chr 1: 172.04 - 172.05 Mb

Pubmed search

[1]

[2]

U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: UHMK1 U2AF homology motif (UHM) kinase 1.

[edit] Further reading

Crook MF, Olive M, Xue HH, et al. (2008). "GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.". FASEB J. 22 (1): 225-35. doi:10.1096/fj.07-8573com. PMID 17726090.
Puri V, McQuillin A, Choudhury K, et al. (2007). "Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene.". Biol. Psychiatry 61 (7): 873-9. doi:10.1016/j.biopsych.2006.06.014. PMID 16978587.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Bièche I, Manceau V, Curmi PA, et al. (2003). "Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human.". Brain Res. Mol. Brain Res. 114 (1): 55-64. PMID 12782393.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Boehm M, Yoshimoto T, Crook MF, et al. (2002). "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.". EMBO J. 21 (13): 3390-401. doi:10.1093/emboj/cdf343. PMID 12093740.
Caldwell BD, Darlington DN, Penzes P, et al. (2000). "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase.". J. Biol. Chem. 274 (49): 34646-56. PMID 10574929.
Maucuer A, Camonis JH, Sobel A (1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3100-4. PMID 7724523.