UGT2B4

From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 2 family, polypeptide B4

Identifiers

UGT2B4; UGT2B11

External IDs

Gene ontology
Molecular Function:	• glucuronosyltransferase activity
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• estrogen catabolic process • xenobiotic metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_021139 (mRNA)
NP_066962 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 4: 70.38 - 70.4 Mb

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Pubmed search

[1]

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UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is a human gene.^[1]

[edit] References

^ Entrez Gene: UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4.

[edit] Further reading

Mackenzie PI, Owens IS, Burchell B, et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.". Pharmacogenetics 7 (4): 255-69. PMID 9295054.
Kadlubar FF, Miller JA, Miller EC (1977). "Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis.". Cancer Res. 37 (3): 805-14. PMID 13929.
Ritter JK, Chen F, Sheen YY, et al. (1992). "Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives.". Biochemistry 31 (13): 3409-14. PMID 1554722.
Fournel-Gigleux S, Jackson MR, Wooster R, Burchell B (1989). "Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture.". FEBS Lett. 243 (2): 119-22. PMID 2492950.
Jackson MR, McCarthy LR, Harding D, et al. (1987). "Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA.". Biochem. J. 242 (2): 581-8. PMID 3109396.
Monaghan G, Clarke DJ, Povey S, et al. (1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.". Genomics 23 (2): 496-9. doi:10.1006/geno.1994.1531. PMID 7835904.
Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.". Biochem. Biophys. Res. Commun. 194 (1): 496-503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
Babu SR, Lakshmi VM, Huang GP, et al. (1996). "Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.". Biochem. Pharmacol. 51 (12): 1679-85. PMID 8687483.
Monaghan G, Burchell B, Boxer M (1997). "Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase.". Mamm. Genome 8 (9): 692-4. PMID 9271674.
King CD, Rios GR, Assouline JA, Tephly TR (1999). "Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.". Arch. Biochem. Biophys. 365 (1): 156-62. doi:10.1006/abbi.1999.1155. PMID 10222050.
Lévesque E, Beaulieu M, Hum DW, Bélanger A (1999). "Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene.". Pharmacogenetics 9 (2): 207-16. PMID 10376768.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164-71. doi:10.1074/jbc.M002180200. PMID 10748067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Barbier O, Torra IP, Sirvent A, et al. (2003). "FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.". Gastroenterology 124 (7): 1926-40. PMID 12806625.
Barbier O, Duran-Sandoval D, Pineda-Torra I, et al. (2003). "Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.". J. Biol. Chem. 278 (35): 32852-60. doi:10.1074/jbc.M305361200. PMID 12810707.
Saeki M, Saito Y, Jinno H, et al. (2005). "Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.". Drug Metab. Dispos. 32 (9): 1048-54. PMID 15319348.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Barre L, Fournel-Gigleux S, Finel M, et al. (2007). "Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.". FEBS J. 274 (5): 1256-64. doi:10.1111/j.1742-4658.2007.05670.x. PMID 17263731.