UGT2B15

From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 2 family, polypeptide B15

Identifiers

External IDs

OMIM: 600069 MGI: 3576100 HomoloGene: 88643

Gene ontology
Molecular Function:	• glucuronosyltransferase activity • transferase activity, transferring hexosyl groups
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• xenobiotic metabolic process • metabolic process • steroid metabolic process

Orthologs

Human

Mouse

n/a

Refseq

NM_001076 (mRNA)
NP_001067 (protein)

NM_172881 (mRNA)
NP_766469 (protein)

Location

n/a

Chr 5: 88.08 - 88.09 Mb

Pubmed search

[1]

[2]

UDP glucuronosyltransferase 2 family, polypeptide B15, also known as UGT2B15, is a human gene.^[1]

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15.

[edit] Further reading

Coffman BL, Tephly TR, Irshaid YM, et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase.". Arch. Biochem. Biophys. 281 (1): 170-5. PMID 2116769.
Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases.". Mol. Pharmacol. 31 (1): 27-34. PMID 3100939.
Green MD, Clarke DJ, Oturu EM, et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.". Arch. Biochem. Biophys. 322 (2): 460-8. doi:10.1006/abbi.1995.1489. PMID 7574722.
Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.". Drug Metab. Dispos. 22 (5): 799-805. PMID 7835232.
Monaghan G, Clarke DJ, Povey S, et al. (1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.". Genomics 23 (2): 496-9. doi:10.1006/geno.1994.1531. PMID 7835904.
Chen F, Ritter JK, Wang MG, et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.". Biochemistry 32 (40): 10648-57. PMID 8399210.
Guillemette C, Lévesque E, Beaulieu M, et al. (1997). "Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells.". Endocrinology 138 (7): 2998-3005. PMID 9202245.
Lévesque E, Beaulieu M, Green MD, et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.". Pharmacogenetics 7 (4): 317-25. PMID 9295060.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.". Biochem. J. 338 ( Pt 2): 489-98. PMID 10024527.
Tchernof A, Lévesque E, Beaulieu M, et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.". Clin. Endocrinol. (Oxf) 50 (5): 637-42. PMID 10468930.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164-71. doi:10.1074/jbc.M002180200. PMID 10748067.
Gsur A, Preyer M, Haidinger G, et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk.". Cancer Epidemiol. Biomarkers Prev. 11 (5): 497-8. PMID 12010866.
Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.". J. Hum. Genet. 47 (10): 505-10. doi:10.1007/s100380200075. PMID 12376738.
Court MH, Duan SX, Guillemette C, et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.". Drug Metab. Dispos. 30 (11): 1257-65. PMID 12386133.
Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression.". Asian J. Androl. 5 (1): 9-13. PMID 12646996.
Zhang JY, Zhan J, Cook CS, et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.". Drug Metab. Dispos. 31 (5): 652-8. PMID 12695355.
Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism.". J. Pediatr. Endocrinol. Metab. 16 (5): 719-26. PMID 12880121.
Court MH, Hao Q, Krishnaswamy S, et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.". J. Pharmacol. Exp. Ther. 310 (2): 656-65. doi:10.1124/jpet.104.067660. PMID 15044558.
Toide K, Umeda S, Yamazaki H, et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15.". Drug Metab. Pharmacokinet. 17 (2): 164-6. PMID 15618667.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.". Endocr. Res. 30 (4): 717-25. PMID 15666817.