UDP-sugar diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-sugar diphosphatase (EC 3.6.1.45) is an enzyme that catalyzes the chemical reaction

UDP-sugar + H₂O $\rightleftharpoons$ UMP + alpha-D-aldose 1-phosphate

Thus, the two substrates of this enzyme are UDP-sugar and H₂O, whereas its two products are UMP and alpha-D-aldose 1-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, and UDP-sugar pyrophosphatase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1HO5, 1HP1, 1HPU, 1OI8, 1OID, and 1OIE.

[edit] References

IUBMB entry for 3.6.1.45
BRENDA references for 3.6.1.45 (Recommended.)
PubMed references for 3.6.1.45
PubMed Central references for 3.6.1.45
Google Scholar references for 3.6.1.45
Garrett AR, Johnson LA, Beacham IR (1989). "Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase". Mol. Microbiol. 3: 177–86. doi:10.1111/j.1365-2958.1989.tb01806.x. PMID 2548058.
Glaser L, Melo A, Paul R (1987). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor". J. Biol. Chem. 242: 1944–1954.