UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase (EC 2.3.2.10) is an enzyme that catalyzes the chemical reaction

L-alanyl-tRNA + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine tRNA + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N₆-(L-alanyl)-L-lysyl-D- alanyl-D-alanine

Thus, the two substrates of this enzyme are L-alanyl-tRNA and UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine, whereas its 3 products are tRNA, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-, and alanyl-D-alanine.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-ala nyl-D-alanine N6-alanyltransferase. Other names in common use include alanyl-transfer ribonucleate-uridine, diphosphoacetylmuramoylpentapeptide transferase, UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase, uridine diphosphoacetylmuramoylpentapeptide lysine, N6-alanyltransferase, L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-, and alanyl-D-alanine 6-N-alanyltransferase. This enzyme participates in peptidoglycan biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1P4N, 1XE4, 1XF8, and 1XIX.

[edit] References

• IUBMB entry for 2.3.2.10
• BRENDA references for 2.3.2.10 (Recommended.)
• PubMed references for 2.3.2.10
• PubMed Central references for 2.3.2.10
• Google Scholar references for 2.3.2.10
• Plapp R, Strominger JL (1970). "Biosynthesis of the peptidoglycan of bacterial cell walls. 18 Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens". J. Biol. Chem. 245: 3675–82. PMID 4248527. 

[edit] External links

The CAS registry number for this enzyme class is 37257-26-4.

• IUBMB entry for 2.3.2.10

• KEGG entry for 2.3.2.10

• BRENDA entry for 2.3.2.10

• NiceZyme view of 2.3.2.10

• EC2PDB: PDB structures for 2.3.2.10

• PRIAM entry for 2.3.2.10

• PUMA2 entry for 2.3.2.10

• IntEnz: Integrated Enzyme entry for 2.3.2.10

• MetaCyc entry for 2.3.2.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047206: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

• AMIGO entry for GO code 0047206: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase