UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase

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In enzymology, an UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + dolichyl phosphate UMP + N-acetyl-D-glucosaminyl-diphosphodolichol

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and dolichyl phosphate, whereas its two products are UMP and N-acetyl-D-glucosaminyl-diphosphodolichol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups transferases for other substituted phosphate groups. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase. Other names in common use include UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase, UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase, UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase, uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase, chitobiosylpyrophosphoryldolichol synthase, dolichol phosphate N-acetylglucosamine-1-phosphotransferase, UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase, and UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase. This enzyme participates in the biosynthesis of n-glycan and glycan structures.

[edit] References

• IUBMB entry for 2.7.8.15
• BRENDA references for 2.7.8.15 (Recommended.)
• PubMed references for 2.7.8.15
• PubMed Central references for 2.7.8.15
• Google Scholar references for 2.7.8.15
• Sharma CB, Lehle L, Tanner W (1982). "Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast". Eur. J. Biochem. 126: 319–25. PMID 6215245. 
• Villemez CL, Carlo PL (1980). "Properties of a soluble polyprenyl phosphate UDP-D-N-acetylglucosamine N-acetylglucosamine-1-phosphate transferase". J. Biol. Chem. 255: 8174–8. PMID 6447695. 

[edit] External links

The CAS registry number for this enzyme class is 70431-08-2.

• IUBMB entry for 2.7.8.15

• KEGG entry for 2.7.8.15

• BRENDA entry for 2.7.8.15

• NiceZyme view of 2.7.8.15

• EC2PDB: PDB structures for 2.7.8.15

• PRIAM entry for 2.7.8.15

• PUMA2 entry for 2.7.8.15

• IntEnz: Integrated Enzyme entry for 2.7.8.15

• MetaCyc entry for 2.7.8.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003975: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase

• AMIGO entry for GO code 0003975: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase