UCHL5

From Wikipedia, the free encyclopedia

Ubiquitin carboxyl-terminal hydrolase L5

Identifiers

UCHL5; CGI-70; UCH37

External IDs

OMIM: 610667 MGI: 1914848 HomoloGene: 9326

Gene ontology
Molecular Function:	• ubiquitin thiolesterase activity • protein binding • cysteine-type peptidase activity • hydrolase activity
Cellular Component:	• intracellular • cytosol • protein complex
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015984 (mRNA)
NP_057068 (protein)

NM_019562 (mRNA)
NP_062508 (protein)

Location

Chr 1: 191.25 - 191.3 Mb

Chr 1: 145.54 - 145.57 Mb

Pubmed search

[1]

[2]

Ubiquitin carboxyl-terminal hydrolase L5, also known as UCHL5, is a human gene.^[1]

[edit] References

^ Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37.". FEBS Lett. 488 (3): 201–5. PMID 11163772.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wicks SJ, Haros K, Maillard M, et al. (2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling.". Oncogene 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389.
Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets.". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146.
Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMID 16990800.
Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMID 17139257.