UBXD5

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UBX domain containing 5
Identifiers
Symbol(s) UBXD5; COA-1; DKFZp686F04228; PP2243; SOC
External IDs OMIM: 609151 MGI: 1914836 HomoloGene: 12159
Orthologs
Human Mouse
Entrez 91544 67586
Ensembl ENSG00000158062 ENSMUSG00000012126
Refseq NM_001077262 (mRNA)
NP_001070730 (protein)		 NM_026257 (mRNA)
NP_080533 (protein)
Location Chr 1: 26.48 - 26.52 Mb Chr 4: 133.37 - 133.4 Mb
Pubmed search [1] [2]

UBX domain containing 5, also known as UBXD5, is a human gene.[1]

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: UBXD5 UBX domain containing 5.

[edit] Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174. 
  • Katoh H, Harada A, Mori K, Negishi M (2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.". Mol. Cell. Biol. 22 (9): 2952-64. PMID 11940653. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Maccalli C, Li YF, El-Gamil M, et al. (2003). "Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes.". Cancer Res. 63 (20): 6735-43. PMID 14583468. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Tateiwa K, Katoh H, Negishi M (2005). "Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation.". Biochem. Biophys. Res. Commun. 337 (2): 615-20. doi:10.1016/j.bbrc.2005.09.097. PMID 16202387. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
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