UBE4A

From Wikipedia, the free encyclopedia

Ubiquitination factor E4A (UFD2 homolog, yeast)

PDB rendering based on 1wgm.

Available structures: 1wgm

Identifiers

Symbol(s)

UBE4A; E4; KIAA0126; MGC133315; UBOX2; UFD2

External IDs

OMIM: 603753 MGI: 2154580 HomoloGene: 3517

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• ubiquitin-dependent protein catabolic process • protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004788 (mRNA)
NP_004779 (protein)

NM_145400 (mRNA)
NP_663375 (protein)

Location

Chr 11: 117.74 - 117.78 Mb

Chr 9: 44.67 - 44.72 Mb

Pubmed search

[1]

[2]

Ubiquitination factor E4A (UFD2 homolog, yeast), also known as UBE4A, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast).

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280.
Koegl M, Hoppe T, Schlenker S, et al. (1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.". Cell 96 (5): 635-44. PMID 10089879.
Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.". Biochem. J. 361 (Pt 3): 587-95. PMID 11802788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues.". Gene 328: 69-74. doi:10.1016/j.gene.2003.11.017. PMID 15019985.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.". Cell Cycle 3 (12): 1638-44. PMID 15611659.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.