UBE2V2

From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2 variant 2

PDB rendering based on 1j74.

Available structures: 1j74, 1j7d, 1zgu, 2a4d, 2c2v, 2hlw

Identifiers

Symbol(s)

UBE2V2; DDVIT1; DDVit-1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2

External IDs

OMIM: 603001 MGI: 1917870 HomoloGene: 55739

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding
Cellular Component:	• nucleus • cytoplasm • UBC13-MMS2 complex
Biological Process:	• regulation of progression through cell cycle • protein polyubiquitination • regulation of DNA repair • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003350 (mRNA)
NP_003341 (protein)

NM_023585 (mRNA)
NP_076074 (protein)

Location

Chr 8: 49.12 - 49.14 Mb

Chr 6: 100.57 - 100.57 Mb

Pubmed search

[1]

[2]

Ubiquitin-conjugating enzyme E2 variant 2, also known as UBE2V2, is a human gene.^[1]

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2.

[edit] Further reading

Fritsche J, Rehli M, Krause SW, et al. (1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes.". Biochem. Biophys. Res. Commun. 235 (2): 407-12. PMID 9199207.
Sancho E, Vilá MR, Sánchez-Pulido L, et al. (1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.". Mol. Cell. Biol. 18 (1): 576-89. PMID 9418904.
Xiao W, Lin SL, Broomfield S, et al. (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.". Nucleic Acids Res. 26 (17): 3908-14. PMID 9705497.
Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.". Cell 96 (5): 645-53. PMID 10089880.
Chan NL, Hill CP (2001). "Defining polyubiquitin chain topology.". Nat. Struct. Biol. 8 (8): 650-2. doi:10.1038/90337. PMID 11473244.
Moraes TF, Edwards RA, McKenna S, et al. (2001). "Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13.". Nat. Struct. Biol. 8 (8): 669-73. doi:10.1038/90373. PMID 11473255.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Bothos J, Summers MK, Venere M, et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.". Oncogene 22 (46): 7101-7. doi:10.1038/sj.onc.1206831. PMID 14562038.
Zhou H, Wertz I, O'Rourke K, et al. (2004). "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.". Nature 427 (6970): 167-71. doi:10.1038/nature02273. PMID 14695475.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Simpson LJ, Sale JE (2005). "UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.". DNA Repair (Amst.) 4 (4): 503-10. doi:10.1016/j.dnarep.2004.12.002. PMID 15725630.
Pastushok L, Moraes TF, Ellison MJ, Xiao W (2005). "A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex.". J. Biol. Chem. 280 (18): 17891-900. doi:10.1074/jbc.M410469200. PMID 15749714.
Spyracopoulos L, Lewis MJ, Saltibus LF (2005). "Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States.". Biochemistry 44 (24): 8770-81. doi:10.1021/bi050065k. PMID 15952783.
Andersen PL, Zhou H, Pastushok L, et al. (2005). "Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.". J. Cell Biol. 170 (5): 745-55. doi:10.1083/jcb.200502113. PMID 16129784.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Wen R, Newton L, Li G, et al. (2006). "Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants.". Plant Mol. Biol. 61 (1-2): 241-53. doi:10.1007/s11103-006-0007-x. PMID 16786304.
Zhao GY, Sonoda E, Barber LJ, et al. (2007). "A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.". Mol. Cell 25 (5): 663-75. doi:10.1016/j.molcel.2007.01.029. PMID 17349954.