UBE2M

From Wikipedia, the free encyclopedia


Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
PDB rendering based on 1y8x.
Available structures: 1y8x, 2nvu
Identifiers
Symbol(s) UBE2M; UBC-RS2; UBC12; hUbc12
External IDs OMIM: 603173 MGI: 108278 HomoloGene: 2952
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9040 22192
Ensembl ENSG00000130725 ENSMUSG00000005575
Uniprot P61081 P61082
Refseq NM_003969 (mRNA)
NP_003960 (protein)		 NM_145578 (mRNA)
NP_663553 (protein)
Location Chr 19: 63.76 - 63.76 Mb Chr 7: 11.94 - 11.94 Mb
Pubmed search [1] [2]

Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), also known as UBE2M, is a human gene.[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.[1]

[edit] References

  1. ^ a b Entrez Gene: UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast).

[edit] Further reading

  • Osaka F, Kawasaki H, Aida N, et al. (1998). "A new NEDD8-ligating system for cullin-4A.". Genes Dev. 12 (15): 2263-8. PMID 9694792. 
  • Gong L, Yeh ET (1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.". J. Biol. Chem. 274 (17): 12036-42. PMID 10207026. 
  • Chen Y, McPhie DL, Hirschberg J, Neve RL (2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.". J. Biol. Chem. 275 (12): 8929-35. PMID 10722740. 
  • Wada H, Yeh ET, Kamitani T (2000). "A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo.". J. Biol. Chem. 275 (22): 17008-15. PMID 10828074. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048-54. doi:10.1074/jbc.M212632200. PMID 12522145. 
  • Huang DT, Miller DW, Mathew R, et al. (2004). "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.". Nat. Struct. Mol. Biol. 11 (10): 927-35. doi:10.1038/nsmb826. PMID 15361859. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Huang DT, Paydar A, Zhuang M, et al. (2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.". Mol. Cell 17 (3): 341-50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336. 
  • Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.". Arch. Biochem. Biophys. 453 (1): 70-4. doi:10.1016/j.abb.2006.03.002. PMID 16620772. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
 This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.