UBAP1

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Ubiquitin associated protein 1
PDB rendering based on 1wgn.
Available structures: 1wgn
Identifiers
Symbol(s) UBAP1; MGC119669; MGC8710; NAG20; UAP; UBAP
External IDs OMIM: 609787 MGI: 2149543 HomoloGene: 9554
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51271 67123
Ensembl ENSG00000165006 ENSMUSG00000028437
Uniprot Q9NZ09 Q3TQY7
Refseq NM_016525 (mRNA)
NP_057609 (protein)		 NM_023305 (mRNA)
NP_075794 (protein)
Location Chr 9: 34.17 - 34.24 Mb Chr 4: 41.54 - 41.58 Mb
Pubmed search [1] [2]

Ubiquitin associated protein 1, also known as UBAP1, is a human gene.[1]

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas.[1]

[edit] References

  1. ^ a b Entrez Gene: UBAP1 ubiquitin associated protein 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Qian J, Yang J, Zhang X, et al. (2001). "Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22.". J. Cancer Res. Clin. Oncol. 127 (10): 613–8. PMID 11599797. 
  • Qian J, Zhang XH, Yang JB, et al.. "Cloning and Expression Analysis of a Novel Gene, UBAP1, Possibly Involved in Ubiquitin Pathway." 33 (2): 147–152. PMID 12050802. 
  • Qian J, Zhang XM, Li XL, et al. (2003). "[Identification of digital differential expression patterns of a novel human gene (UBAP1) by an expressed sequence tag strategy]". Ai Zheng 21 (3): 225–8. PMID 12451983. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Xiao B, Fan S, Zeng Z, et al. (2007). "Purification of novel UBAP1 protein and its decreased expression on nasopharyngeal carcinoma tissue microarray.". Protein Expr. Purif. 47 (1): 60–7. doi:10.1016/j.pep.2005.08.026. PMID 16226037. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
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