U6atac minor spliceosomal RNA

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U6atac minor spliceosomal RNA

Type:	Gene;snRNA;splicing;
2° structure:	PMID:10199569; Daub J
Seed alignment:	Published; PMID:11911359
Avg length:	120.3 nucleotides
Avg identity:	67%

U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type) ^[1].

U6atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U4atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing ^[2]. U6atac is the functional analog of U6 spliceosomal RNA in the major U2-type spliceosomal complex^[2].

[edit] References

^ Lorkovic ZJ, Lehner R, Forstner C, Barta A; (2005). "Evolutionary conservation of minor U12-type spliceosome betweenplants and humans.". RNA 11: 1095–1107. doi:10.1261/rna.2440305. PMID 15987817.
^ ^a ^b Padgett RA, Shukla GC; (2002). "A revised model for U4atac/U6atac snRNA base pairing.". RNA 8: 125–128. doi:10.1017/S1355838202017156. PMID 11911359.

Shukla GC, Padgett RA; (1999). "Conservation of functional features of U6atac and U12 snRNAs betweenvertebrates and higher plants.". RNA 5: 525–538. doi:10.1017/S1355838299982213. PMID 10199569.