Tyrosine-ester sulfotransferase

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In enzymology, a tyrosine-ester sulfotransferase (EC 2.8.2.9) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + L-tyrosine methyl ester $\rightleftharpoons$ adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and L-tyrosine methyl ester, whereas its two products are adenosine 3',5'-bisphosphate and L-tyrosine methyl ester 4-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase. Other names in common use include aryl sulfotransferase IV, and L-tyrosine methyl ester sulfotransferase.

[edit] References

IUBMB entry for 2.8.2.9
BRENDA references for 2.8.2.9 (Recommended.)
PubMed references for 2.8.2.9
PubMed Central references for 2.8.2.9
Google Scholar references for 2.8.2.9
Duffel MW, Jakoby WB (1981). "On the mechanism of aryl sulfotransferase". J. Biol. Chem. 256: 11123–7. PMID 6945304.
Mattock P, Jones JG (1970). "Partial purification and properties of an enzyme from rat liver that catalyses the sulphation of L-tyrosyl derivatives". Biochem. J. 116: 797–803. PMID 5441369.
Sekura RD, Jakoby WB (1981). "Aryl sulfotransferase IV from rat liver". Arch. Biochem. Biophys. 211: 352–9. PMID 6946725.