TXNDC5

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Thioredoxin domain containing 5
PDB rendering based on 2diz.
Available structures: 2diz
Identifiers
Symbol(s) TXNDC5; ERP46; EndoPDI; MGC3178; UNQ364
External IDs MGI: 2145316 HomoloGene: 11125
Orthologs
Human Mouse
Entrez 81567 105245
Ensembl n/a ENSMUSG00000038991
Uniprot n/a Q3TEE8
Refseq NM_022085 (mRNA)
NP_071368 (protein)		 XM_975097 (mRNA)
XP_980191 (protein)
Location n/a Chr 13: 38.51 - 38.54 Mb
Pubmed search [1] [2]

Thioredoxin domain containing 5, also known as TXNDC5, is a human gene.[1]

This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MU.[1]

[edit] References

  1. ^ a b Entrez Gene: TXNDC5 thioredoxin domain containing 5.

[edit] Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Neve EP, Svensson K, Fuxe J, Pettersson RF (2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum.". Exp. Cell Res. 288 (1): 70–83. PMID 12878160. 
  • Knoblach B, Keller BO, Groenendyk J, et al. (2006). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.". Mol. Cell Proteomics 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873. 
  • Sullivan DC, Huminiecki L, Moore JW, et al. (2004). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor.". J. Biol. Chem. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. 
  • Nissom PM, Lo SL, Lo JC, et al. (2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma.". FEBS Lett. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106. 
  • Wang Y, Ma Y, Lü B, et al. (2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.". Exp. Biol. Med. (Maywood) 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523. 
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