TXK (gene)

From Wikipedia, the free encyclopedia

TXK tyrosine kinase

PDB rendering based on 2dm0.

Available structures: 2dm0

Identifiers

Symbol(s)

TXK; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL

External IDs

OMIM: 600058 MGI: 102960 HomoloGene: 2497

Gene ontology
Molecular Function:	• nucleotide binding • non-membrane spanning protein tyrosine kinase activity • ATP binding • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003328 (mRNA)
NP_003319 (protein)

NM_013698 (mRNA)
NP_038726 (protein)

Location

Chr 4: 47.76 - 47.83 Mb

Chr 5: 72.98 - 73.02 Mb

Pubmed search

[1]

[2]

TXK tyrosine kinase, also known as TXK, is a human gene.^[1]

[edit] References

^ Entrez Gene: TXK TXK tyrosine kinase.

[edit] Further reading

Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.". Clinical medicine & research 4 (2): 147-51. PMID 16809408.
Spritz RA, Strunk KM, Lee ST, et al. (1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.". Genomics 22 (2): 431-6. doi:10.1006/geno.1994.1405. PMID 7528718.
Haire RN, Ohta Y, Lewis JE, et al. (1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12.". Hum. Mol. Genet. 3 (6): 897-901. PMID 7951233.
Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.". Oncogene 12 (4): 937-42. PMID 8632917.
Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.". J. Biol. Chem. 271 (33): 19641-4. PMID 8702662.
Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.". Immunity 6 (2): 155-64. PMID 9047237.
Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.". Biochem. Biophys. Res. Commun. 252 (1): 14-9. doi:10.1006/bbrc.1998.9559. PMID 9813138.
Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657-68. PMID 10587356.
Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.". J. Biol. Chem. 275 (6): 3835-40. PMID 10660534.
Chamorro M, Czar MJ, Debnath J, et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.". BMC Immunol. 2: 3. PMID 11353545.
Takeba Y, Nagafuchi H, Takeno M, et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.". J. Immunol. 168 (5): 2365-70. PMID 11859127.
Kashiwakura J, Suzuki N, Takeno M, et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.". Biol. Pharm. Bull. 25 (6): 718-21. PMID 12081135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.". Hum. Mol. Genet. 13 (15): 1535-49. doi:10.1093/hmg/ddh167. PMID 15175272.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.