Talk:Tumor necrosis factor-alpha

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I found some historical information here. JFW | T@lk 12:00, 11 December 2005 (UTC)

--- why is it called 'tumor necrosis factor' -- some background would be good, I'll see what I can find --hmackiernan


"Inhibition of TNFα promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, and psoriasis. These disorders are sometimes treated by inhibiting TNFα "

This seems contradictory. If inhibition of TNFa promotes the inflammatory response, why would you treat these conditions by inhibiting TNFa??

I noticed the above contradiction as well and think the first part of the phrase must be an error. However, I'm not a medical expert, so I don't dare edit the TNF page.

I removed the offending phrase (as I am about to refer people to the page). Out of curiosity, I just went back and checked the history. It was clearly an editing glitch, with the phrase left over from what is now covered in the second sentence. -- Bob Kerns

Contents

[edit] viral replication

doesnt tnf block instead of cause viral replication??? -Sucrine ( ><> talk) 14:52, 19 January 2007 (UTC)


How about Tumor Necrosis Factor beta? It is not discussed at all in this page. TNF-alpha is involved in Toxic Shock Syndrome among other things. I can't find any decent (recent) reviews on the topic.

[edit] disabling auto updates

Arcadian, just wondering why you chose to disable all updates of the ProteinBoxBot. Clearly this is a pretty mature article so the impact of PBB edits is proportionally less. (And this was also one of our first edits, and in retrospect, I would not have added the summary and further reading sections where reasonable summaries and reference lists exist.) Was there a particular reason you also wanted to disable the infobox updates? Not trying to convince you otherwise, just trying to understand for the purposes of making sure PBB plays nicely with human editors... AndrewGNF 18:01, 13 November 2007 (UTC)

[edit] More general entry: TNF, then subheadings TNF-alpha, TNF-beta?

I'm currently studying this stuff, so I'm no expert, but I'm noticing some confusion. Wouldn't it make sense to merge the entry on TNF with the present one? It could start with a general discussion of TNF and then differentiate between the two types. 85.178.26.162 (talk) 13:30, 6 January 2008 (UTC)

[edit] the first sentence is very good. can you do the same for osteoclast activating factor

osteoclast activating factor has a bunch of different names that it goes by and I think it has sorta evolved with time. I am impressed by the first sentence / alternate names of TNF-alpha and wish someone would do the same for Osteoclast activating factor. Off the top of my head I think it is IL-6 and a subtype of IL-1. But I'm probably wrong so please verify. —Preceding unsigned comment added by 75.43.212.236 (talk) 07:53, 28 April 2008 (UTC)

http://www.google.com/search?q=osteoclast+activating+factor&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a
http://www.grt.kyushu-u.ac.jp/spad/account/ligand/il1.html
http://www.google.com/search?hl=en&safe=off&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=9EO&q=osteoclast+activating+factor+IL-1&btnG=Search —Preceding unsigned comment added by 75.43.212.236 (talk) 07:56, 28 April 2008 (UTC)