TUFM

From Wikipedia, the free encyclopedia

Tu translation elongation factor, mitochondrial

PDB rendering based on 1d2e.

Available structures: 1d2e, 1xb2

Identifiers

Symbol(s)

TUFM; COXPD4; EF-TuMT; EFTU

External IDs

OMIM: 602389 MGI: 1923686 HomoloGene: 2490

Gene ontology
Molecular Function:	• nucleotide binding • translation elongation factor activity • GTPase activity • GTP binding
Cellular Component:	• intracellular • mitochondrion
Biological Process:	• translational elongation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003321 (mRNA)
NP_003312 (protein)

NM_172745 (mRNA)
NP_766333 (protein)

Location

Chr 16: 28.76 - 28.77 Mb

Chr 7: 126.28 - 126.28 Mb

Pubmed search

[1]

[2]

Tu translation elongation factor, mitochondrial, also known as TUFM, is a human gene.^[1]

[edit] References

^ Entrez Gene: TUFM Tu translation elongation factor, mitochondrial.

[edit] Further reading

Wells J, Henkler F, Leversha M, Koshy R (1995). "A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues.". FEBS Lett. 358 (2): 119–25. PMID 7828719.
Woriax VL, Burkhart W, Spremulli LL (1996). "Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu.". Biochim. Biophys. Acta 1264 (3): 347–56. PMID 8547323.
Ling M, Merante F, Chen HS, et al. (1997). "The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene.". Gene 197 (1-2): 325–36. PMID 9332382.
Shah ZH, Migliosi V, Miller SC, et al. (1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus.". Genomics 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID 9545647.
Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation.". J. Biol. Chem. 277 (10): 8388–94. doi:10.1074/jbc.M108792200. PMID 11741979.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.
Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA (2006). "The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1.". Hum. Mol. Genet. 15 (11): 1835–46. doi:10.1093/hmg/ddl106. PMID 16632485.
Smeitink JA, Elpeleg O, Antonicka H, et al. (2006). "Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs.". Am. J. Hum. Genet. 79 (5): 869–77. doi:10.1086/508434. PMID 17033963.
Valente L, Tiranti V, Marsano RM, et al. (2007). "Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu.". Am. J. Hum. Genet. 80 (1): 44–58. doi:10.1086/510559. PMID 17160893.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.