TUBB

From Wikipedia, the free encyclopedia

Tubulin, beta

PDB rendering based on 1ffx.

Available structures: 1ffx, 1ia0, 1jff, 1sa0, 1sa1, 1tub, 1tvk, 1z2b, 2hxf, 2hxh

Identifiers

Symbol(s)

TUBB; TUBB5; TUBB1; M40; MGC117247; MGC16435; OK/SW-cl.56

External IDs

OMIM: 191130 MGI: 107812 HomoloGene: 69099

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • structural molecule activity • structural constituent of cytoskeleton • GTP binding • MHC class I protein binding
Cellular Component:	• cytoplasm • cytoskeleton • microtubule • protein complex
Biological Process:	• cell motility • microtubule-based movement • natural killer cell mediated cytotoxicity • spindle assembly • protein polymerization

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_178014 (mRNA)
NP_821133 (protein)

NM_011655 (mRNA)
NP_035785 (protein)

Location

n/a

Chr 17: 35.44 - 35.45 Mb

Pubmed search

[1]

[2]

Tubulin, beta, also known as TUBB, is a human gene.^[1]

[edit] See also

Tubulin

[edit] References

^ Entrez Gene: TUBB tubulin, beta.

[edit] Further reading

Berrieman HK, Lind MJ, Cawkwell L (2004). "Do beta-tubulin mutations have a role in resistance to chemotherapy?". Lancet Oncol. 5 (3): 158–64. doi:10.1016/S1470-2045(04)01411-1. PMID 15003198.
Horisberger MA (1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins.". J. Virol. 66 (8): 4705–9. PMID 1629950.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype.". J. Cell Biol. 103 (5): 1903–10. PMID 3782288.
Lee MG, Lewis SA, Wilde CD, Cowan NJ (1983). "Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes.". Cell 33 (2): 477–87. PMID 6688039.
Hall JL, Dudley L, Dobner PR, et al. (1983). "Identification of two human beta-tubulin isotypes.". Mol. Cell. Biol. 3 (5): 854–62. PMID 6865944.
Volz A, Weiss E, Trowsdale J, Ziegler A (1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.". Hum. Genet. 93 (1): 42–6. PMID 8270253.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Kinnunen T, Kaksonen M, Saarinen J, et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.". J. Biol. Chem. 273 (17): 10702–8. PMID 9553134.
Niethammer M, Valtschanoff JG, Kapoor TM, et al. (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.". Neuron 20 (4): 693–707. PMID 9581762.
Rasmussen RK, Ji H, Eddes JS, et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins.". Electrophoresis 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920.
Ciruela F, Robbins MJ, Willis AC, McIlhinney RA (1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin.". J. Neurochem. 72 (1): 346–54. PMID 9886087.
Chau MF, Radeke MJ, de Inés C, et al. (1999). "The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains.". Biochemistry 37 (51): 17692–703. PMID 9922135.
Piredda L, Farrace MG, Lo Bello M, et al. (1999). "Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis.". FASEB J. 13 (2): 355–64. PMID 9973324.
Feng Y, Hodge DR, Palmieri G, et al. (1999). "Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex.". Biochem. J. 339 ( Pt 2): 435–42. PMID 10191277.
Martín L, Fanarraga ML, Aloria K, Zabala JC (2000). "Tubulin folding cofactor D is a microtubule destabilizing protein.". FEBS Lett. 470 (1): 93–5. PMID 10722852.
Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity.". J. Immunol. 165 (12): 6776–82. PMID 11120798.
Bonnet C, Boucher D, Lazereg S, et al. (2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation.". J. Biol. Chem. 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
Crabtree DV, Ojima I, Geng X, Adler AJ (2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site.". Bioorg. Med. Chem. 9 (8): 1967–76. PMID 11504633.
Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin.". Biochem. J. 363 (Pt 3): 599–608. PMID 11964161.