TUBB3

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Tubulin, beta 3
PDB rendering based on 1ffx.
Available structures: 1ffx, 1ia0, 1jff, 1sa0, 1sa1, 1tub, 1tvk, 1z2b, 2hxf, 2hxh
Identifiers
Symbol(s) TUBB3; MC1R; TUBB4; beta-4
External IDs OMIM: 602661 MGI: 107813 HomoloGene: 68503
Orthologs
Human Mouse
Entrez 10381 22152


Refseq NM_006086 (mRNA)
NP_006077 (protein)		 NM_023279 (mRNA)
NP_075768 (protein)
Pubmed search [1] [2]

Tubulin, beta 3, also known as TUBB3, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TUBB3 tubulin, beta 3.

[edit] Further reading

  • Venter JC (1993). "Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing.". J. Pharm. Pharmacol. 45 Suppl 1: 355-60. PMID 8098743. 
  • Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum.". EMBO J. 7 (8): 2311-9. PMID 2461292. 
  • Vinores SA, Derevjanik NL, Mahlow J, et al. (1995). "Class III beta-tubulin in human retinal pigment epithelial cells in culture and in epiretinal membranes.". Exp. Eye Res. 60 (4): 385-400. PMID 7789418. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Khan IA, Ludueña RF (1996). "Phosphorylation of beta III-tubulin.". Biochemistry 35 (12): 3704-11. doi:10.1021/bi951247p. PMID 8619990. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Ranganathan S, Dexter DW, Benetatos CA, Hudes GR (1998). "Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents.". Biochim. Biophys. Acta 1395 (2): 237-45. PMID 9473684. 
  • Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings.". J. Cell Biol. 150 (2): 349-60. PMID 10908577. 
  • Sánchez Más J, Olivares Sánchez C, Ghanem G, et al. (2003). "Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.". Eur. J. Biochem. 269 (24): 6133-41. PMID 12473109. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.". EMBO J. 21 (24): 6801-10. PMID 12486001. 
  • Rosell R, Scagliotti G, Danenberg KD, et al. (2003). "Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer.". Oncogene 22 (23): 3548-53. doi:10.1038/sj.onc.1206419. PMID 12789263. 
  • Hari M, Yang H, Zeng C, et al. (2004). "Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel.". Cell Motil. Cytoskeleton 56 (1): 45-56. doi:10.1002/cm.10132. PMID 12905530. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.". J. Biol. Chem. 279 (46): 48197-204. doi:10.1074/jbc.M406195200. PMID 15331610. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mozzetti S, Ferlini C, Concolino P, et al. (2005). "Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.". Clin. Cancer Res. 11 (1): 298-305. PMID 15671559. 
  • de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization.". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMID 15691386. 
  • Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMID 15698476. 
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